Research area

Cell migration and biomechanics

On one hand, to comprehend and describe, with precision, the cellular migration is essential to understand many physiological and pathological processes involved in embryonic morphogenesis, wounds healing, and cancer metastasis. On the other hand, it has been clear that interdisciplinary scientific research is indispensable due to the growing complexity of the problems that we want to resolve.

In the first three years of investigation, the Millennial Nucleus worked with cellular tissues studying fish embryos. Image advanced tools helped to visualize the temporal evolution of epithelial tissues and the migratory cells with the possibility of manipulating, in real-time, its mechanical properties.

The aim was to describe the motions and organization of individual cells and epitheliums using the active matter tools to calculate the mechanical forces and predict forms of self-organization.

The aim of the Millennial Nucleus in this new stage (2021-2023) is to incorporate an analytical vision of cellular migration and biomechanics through the construction of theoretical models with physics tools like molecular dynamics, fluids mechanics, elasticity theory, and statistical mechanics.

The construction of models to describe biological systems would provide the comprehension of the underlying mechanisms in each one of the particular phenomena we want to study.

Researcher responsible:
Néstor Sepúlveda